Meclozine and Foetal Malformations: a Prospective Study.

نویسندگان

  • R W SMITHELLS
  • E R CHINN
چکیده

Bett, I. M. (1962). Ann. rheum. Dis., 21, 388. Biechl, A., Stapleton, J. E., Woodbury, J. F. L., and Read, H. C. (1962). Canad. med. Ass. 7., 86, 401. British Medical Association (1950). Report of Special Committee on Nutrition. B.M.A., London. Chanarin, I., Laidlaw, J., Loughridge, L. W., and Mollin, D. L. (1960). Brit. med. 7., 1, 1099. Mollin, D. L., and Anderson, B. B. (1958). Proc. roy. Soc. Med., 51, 757. Dacie, J. V. (1956). Practical Haematology, 2nd ed. Churchill, London. Dawbarn, M. C., Hine, D. C., and Smith, J. (1958). Aust. 7. exp. Biol. med. Sci., 36, 511. Doig, A., Girdwood, R. H., Duthie, J. J. R., and Knox, J. D. E. (1957). Lancet, 2, 966. Forshaw, J. (1963). Brit. med. 7., 1, 328. Girdwood, R. H. (1953). Ibid., 2, 741. Read, A. E.. McCarthy, C. F., and Waters, A. H. (1963). Quart. 7. Med., 32, 243. Gough, K. R., Mollin, D. L., and Read, A. E. (1962). Paper presented to Scientific Meeting, Royal College of Physicians, London. Herbert, V. (1962). Arch. intern. Med., 110, 649. Kay, A. W. (1953). Brit. med. Y., 2, 77. Kohn, J., Mollin, D. L, and Rosenbach, L. M. (1961). 7. clin. Path., 14, 345. Lewis, S. M., and Porter, I. H. (1960). Ann. rheum. Dis., 19, 54. Matthews, D. M. (1962). Clin. Sci., 22, 101. McCance, R. A., and Widdowson, E. M. (1960). Spec. Rep. Ser. med. Res. Coun. (Lond.), No. 297. Mollin, D. L. (1960). Ann. Rev. Med., 11, 333. Waters, A. H., and Harris, E. (1962). In Vitamin B,, and Intrinsic Factor, edited by H. C. Heinrich, p. 737. Enke, Stuttgart. Gough, K R., and Read, A. E. (1963). Brit. med. Y., 1, 609. National Food Survey (1960). Annual Report, 1958. H.M.S.O.j London. Partridge, R. E. H., and Duthie, J. J. R. (1963). Brit. med. Y., 1, 89. Read, A. E.. Gough, K. R., Bones, J. A., and McCarthy, C. F. (1962). Lancet, 1, 894. Robson, H. N., and Lawrencc, R (1959). Brit. med. Y., 2, 475. Romine, M. K. (1960). 7. Vitamninol., 6, 196. Schilling, R. F. (1954). Fed. Proc., 13, 769. Scott, J. T., Porter, I. H., Lewis, S. M., and Dixon, A. St. J. (1961). Quart. 7. Med., 30, 167. Spray, G. H. (1955). Clin. Sci., 14, 661, 667. Waters, A. H., and Mollin, D. L. (1961). 7. clin. Path., 14, 335. Whiteside, M., Mollin, D. L., Coghill, N. F., and Anderson, B. B. To be published. Will, J. J., Mueller, J. F., Brodine, C., Kiely, C. E., Friedman, B., Hawkins, V. R., Dutra, J., and Vilter, R. W. (1959). 7. Lab. cln. Med., 53, 22.

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عنوان ژورنال:
  • British medical journal

دوره 1 5377  شماره 

صفحات  -

تاریخ انتشار 1964